张晨

博士、高聘副研究员、硕士生导师

个人简介

张晨，男，西北农林科技大学水生生物学博士、参与国家自然科学基金、陕西省自然科学基础研究计划、广西自然科学基金项目等课题多项。海南大学E类高层次引进人才。以第一作者在Journal of Nanobiotechnology、ACS Applied Materials & Interfaces、Microbiology Spectrum、Aquaculture、Antiviral Research、ACS Biomaterials Science & Engineering、Vaccine等期刊发表SCI论文16篇，总影响因子86.6。担任Journal of Advanced Research、Aquaculture和Plos One等期刊审稿人。

研究方向

主要从事水产动物病害防控方面的研究，主要包括水产疫苗优势抗原设计、水产纳米载疫苗系统研究、鱼类获得性免疫机制研究和鱼类肠道微生物与免疫的关系研究。

代表性成果

[1] Zhang Chen^#, Zhao Zhao, Yi-Jun Jia, Peng-Qi Zhang, Yun Sun, Yong-Can Zhou, Wang Gao-Xue*, Zhu Bin*. Rationally designed self-assembling nanovaccines elicit robust mucosal and systemic immunity against rhabdovirus. ACS Applied Materials & Interfaces. 2024. 16:228-244.（副封面文章）

[2] Zhang Chen^#, Wang Gao-Xue, Zhu Bin*. Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism. Journal of Nanobiotechnology. 2020. 18:24.

[3] Zhang Chen^#, Zhao Zhao, Guo Sheng, Peng-Qi Zhang, Zhu Bin. TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. Antiviral Research. 2022. 203:105346.

[4] Zhang Chen^#, Li Lin-Han, Wang Jin, Zhao Zhao, Li Jian, Tu Xiao, Huang Ai-Guo, Wang Gao-Xue*, Zhu Bin*. Enhanced protective immunity against spring viremia of carp virus infection can be induced by recombinant subunit vaccine conjugated to single-walled carbon nanotubes. Vaccine. 2018. 36:6334-6344.

[5] Zhang Chen^#, Peng-Qi Zhang, Guo Sheng, Zhao Zhao, Wang Gao-Xue*, Zhu Bin*. Dual-targeting polymer nanoparticles efficiently deliver DNA vaccine and induce robust prophylactic immunity against spring viremia of carp virus infection. Microbiology Spectrum. 2022. 10:5.

[6] Zhang Chen^#, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Mucosal delivery of mannose functionalized biomimetic nanoparticles via the branchial route induces robust mucosal and systemic immune responses against fish viral disease. Aquaculture. 2022. 546:737329.

[7] Zhang Chen^#, Zhao Zhao, Li Jian, Song Kai-Ge, Hao Kai, Wang Jin, Wang Gao-Xue, Zhu Bin*. Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus. Aquaculture. 2019. 504:361-368.

[8] Zhang Chen^#, Zhao Zhao, Zha Ji-Wei, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of a DNA vaccine against spring viremia of carp virus in common carp. Fish & Shellfish Immunology. 2017. 71:191-201.

[9] Zhang Chen^#, Guo Sheng, Zhao Zhao, Guo Zi-Rao, Ma Rui, Wang Gao-Xue, Zhu Bin*. Surface display of spring viremia of carp virus glycoprotein on Lactococcus lactis and its protection efficacy in common carp (Cyprinus carpio L.). Fish & Shellfish Immunology. 2020. 104:262-268.

[10] Zhang Chen^#, Zhao Zhao, Liu Gao-Yang, Li Jian, Wang Gao-Xue*, Zhu Bin*. Immune response and protective effect against spring viremia of carp virus induced by intramuscular vaccination with a SWCNTs-DNA vaccine encoding matrix protein. Fish & Shellfish Immunology. 2018. 79:256-264.

[11] Zhang Chen^#, Zhang Peng-Qi, Guo Sheng, Chen Guo, Zhao Zhao, Wang Gao-Xue, Zhu Bin*. Application of biomimetic cell-derived nanoparticles with mannose modification as a novel vaccine delivery platform against teleost fish viral disease. ACS Biomaterials Science & Engineering. 2020. 6:6770-6777.

[12] Zhang Chen^#, Zheng Yu-Ying, Gong Yu-Ming, Zhao Zhao, Guo Zi-Rao, Jia Yi-Jun, Wang Gao-Xue, Zhu Bin*. Evaluation of immune response and protection against spring viremia of carp virus induced by a single-walled carbon nanotubes-based immersion DNA vaccine. Virology. 2019. 537:216-225.

[13] Zhu Bin*^#, Zhang Chen^#, Zhao Zhao, Wang Gao-Xue. Targeted delivery of mannosylated nanoparticles improve prophylactic efficacy of immersion vaccine against fish viral disease. Vaccines. 2020. 8:87.

[14] Zhu Bin*^#, Zhang Chen^#, Yang Ben, Guo Zi-Rao, Zheng Yu-Ying, Gong Yu-Ming, Wang Gao-Xue*. Preliminary screening and immunogenicity analysis of antigenic epitopes of spring viremia of carp virus. Fish & Shellfish Immunology. 2019. 94:833-841.

[15] Zheng Yu-Ying^#, Zhang Chen^#, Li Yang, Zhang Peng-Qi, Chen Guo, Wang Gao-Xue, Zhu Bin*. Immersion immunization of common carp with bacterial ghost-based DNA vaccine induces prophylactic protective immunity against spring viremia of carp virus. Journal of Fish Diseases. 2021. 44:2021-2029.

[16] Gong Yu-Ming^#, Zhang Chen^#, Li Yang, Chen Guo, Wang Gao-Xue, Zhu Bin*. Optimization of immunization procedure for SWCNTs-based subunit vaccine with mannose modification against spring viremia of carp virus in common carp. Journal of Fish Diseases. 2021. 44:1925-1936.

招生专业

水产学术硕士、渔业发展专业硕士，欢迎同学们积极联系报考。

联系方式

电子邮箱：bestzc1994@126.com