曾艳华

副研究员、博士生导师、海南自由贸易港D类人才

个人简介

2018年毕业于浙江大学，获环境科学专业博士学位；2018-2021年在清华大学生物学流动站从事博士后研究工作；2022年1月入职海南大学，海洋微生物资源开发与利用创新团队骨干成员。主持国家自然科学基金项目2项、海南省重点研发“揭榜挂帅”项目子课题1项、海南省自然科学基金面上项目1项及广东省基础与应用基础研究青年基金项目1项；发表SCI论文10余篇。主要从事海洋微生物互作关系与分子机制研究。

研究方向

1.水产养殖环境中的微生物互作关系与机制（信号交流、营养竞争、细菌捕食等）研究；

2.基于微生物互作的关键水产益生菌资源挖掘及其功能解析；

3.基于合成微生物组的水产微生物制剂开发与应用。

主持科研项目

1.国家自然科学基金地区基金项目，32460930，代谢产物驱动的哈维氏弧菌和海藻希瓦氏菌互作机制研究，2025.01-2028.12，32万元，主持，在研。

2.国家自然科学基金青年基金项目，32303063，铁载体受体介导的细菌种间互作调控溶藻弧菌生存和毒力的分子机制，2024.01-2026.12，30万元，主持，在研。

3.海南省自然科学基金面上项目，324MS022，特基拉芽孢杆菌群体感应淬灭剂的鉴定及其拮抗水产病原弧菌的分子机制研究，2024.03-2026.02，8万元，主持，在研。

4.海南省重点研发项目“揭榜挂帅”专项子课题，ZDYF2022XDNY349，东星斑循环水养殖及无损病毒筛查技术研究与示范，2022.10-2024.10，44.1万元，主持，在研。

代表性论文

1. Zeng YH, Chen HM, Gong XX, Jiang MW, Liu N, Li W, Zhang N, Long H, Huang AY, Xie ZY*. Probiotic paradox: bacillibactin from Bacillus velezensis drives pathogenic Vibrio alginolyticus proliferation through siderophore piracy. ISME Communications. 2025, 5(1):ycaf132.

2. Zeng YH, Li W, Xu H, Gong XX, Zhang YM, Long H, Xie ZY*. Dual RNA-Seq Unveils Candidate Key Virulence Genes of Vibrio harveyi at the Early Stage of Infection in Hybrid Grouper (♀ Epinephelus polyphekadion × ♂ E. fuscoguttatus). Microorganisms. 2024, 12(11):2113.

3. Gong XX, Zeng YH^#, Chen HM, Zhang N, Han Y, Long H, Xie ZY*. Bioinformatic and functional characterization of cyclic-di-GMP metabolic proteins in Vibrio alginolyticus unveils key diguanylate cyclases controlling multiple biofilm-associated phenotypes. Frontiers in Microbiology. 2023, 14:1258415.

4. Xu H, Zeng YH^#, Yin WL, Lu HB, Gong XX, Zhang N, Zhang X, Long H, Ren W, Cai XN, Huang AY, Xie ZY*. Prevalence of bacterial coinfections with Vibrio harveyi in the industrialized flow-through aquaculture systems in Hainan province: A neglected high-risk lethal causative agent to hybrid grouper. International Journal of Molecular Sciences. 2022, 23(19):11628.

5. Zeng YH, Cai ZH, Cheng KK, Zhou J*. Naturally occurring lasso peptides as algicidal agents against Microcystis aeruginosa. Journal of Cleaner Production. 2022, 135136.

6. Zeng YH, Cheng KK, Cai ZH, Zhu JM, Du XP, Wang Y, Zhou J*. Transcriptome analysis expands the potential roles of quorum sensing in biodegradation and physiological responses to microcystin. Science of the Total Environment. 2021, 771:145437.

7. Zeng YH, Cai ZH, Zhu JM, Du XP, Zhou J*. Two hierarchical LuxR-LuxI type quorum sensing systems in Novosphingobium activate microcystin degradation through transcriptional regulation of the mlr pathway. Water Research. 2020, 183:116092.

8. Zeng YH, Wang YL, Yu ZL, Huang YL*. Hypersensitive response of plasmid-encoded AHL synthase gene to lifestyle and nutrient by Ensifer adhaerens X097. Frontiers in Microbiology. 2017, 8:1160.

9. Wang ZY, Zeng YH, Cheng KK, Cai ZH, Zhou J*. The quorum sensing system of Novosphingobium sp. ERN07 regulates aggregate formation that promotes cyanobacterial growth. Science of the Total Environment. 2022, 851(Pt 2):158354.

10. Zhang SJ, Zeng YH, Zhu JM, Cai ZH, Zhou J*. The structure and assembly mechanisms of plastisphere microbial community in natural marine environment. Journal of Hazardous Materials. 2022, 421:126780.

11. Gao C, Zeng YH, Li CY, Li L, Cai ZH, Zhou J*. Bisphenol A biodegradation by Sphingonomas sp. YK5 is regulated by acyl-homoserine lactone signaling molecules. Science of the Total Environment. 2022, 802:149898.

12. Feng SB, Zeng YH, Cai ZH, Wu JJ, Chan LL, Zhu JM, Zhou J*. Polystyrene microplastics alter the intestinal microbiota function and the hepatic metabolism status in marine medaka (Oryzias melastigma). Science of the Total Environment. 2021, 759:143558.

13. Yin WL, Xie ZY*, Zeng YH, Zhang J, Long H, Ren W, Zhang X, Cai XN, Huang AY. Two (p)ppGpp synthetase genes, relA and spoT, are involved in regulating cell motility, EPSs production and biofilm formation of Vibrio alginolyticus. Frontiers in Microbiology. 2022, 13:858559.

主讲课程

水产养殖生态学

招生专业

水产、渔业发展

联系方式

邮箱：zengyanhua@hainanu.edu.cn

办公地点：南海海洋资源利用国家重点实验室621