曹贞洁

博士、副教授、博士生导师

个人简介

海南大学水生生物学博士，博士后。海南大学D类高层次引进人才，入选海南省自由贸易港D类高层次人才计划。主持国家自然科学基金青年基金1项，海南省重点研发项目1项，海南省自然科学基金1项，海南大学科研启动基金项目1项，海南省博士后面上项目1项。参与国家重点研发计划、国家自然科学基金、海南省重大科技专项、海南省重点研发等课题多项。出版专著1部，发表高水平学术论文20余篇（第一或通讯作者发表SCI论文14篇），授权国际发明专利1项，国内发明专利2项。

学术成果

长期开展卵形鲳鲹、驼背鲈等海水鱼类免疫相关分子及其作用机制等研究，为鱼类健康养殖提供新的策略。目前研究方向主要集中在以下三方面：

1. 热带鱼类的免疫应答机制及病害防控

2. 热带鱼类免疫增强剂的研发与应用

3. 热带鱼类重要病原的快速检测技术研发

研究项目

1. 国家自然科学基金青年基金，卵形鲳鲹Bcl-2/Bok介导的线粒体凋亡途径参与机体免疫应答的作用和机制研究，2024.01-2026.12，主持，在研；

2. 海南省重点研发计划项目，基于多重可视化LAMP的石斑鱼类重要病原多目标检测技术研发与初步应用，2022.03.16-2024.03.16，主持，在研；

3. 海南省自然科学基金青年基金项目，卵形鲳鲹NK-lysin的抗菌机制及其介导的先天免疫应答研究，2020.12.26-2023.12.25，主持，结题；

4. 海南省博士后基金面上资助，驼背鲈MHC基因多态性分析及其与鱼体抗病力相关性研究，2017.11-2019.07，主持，结题；

5. 海南大学高层次人才科研启动项目，热带海水鱼类的主要免疫相关基因及其抗病机制研究，2019.12-2024.12, 100万元，主持，在研

代表性成果

1. Zhenjie Cao#1, Xin Yang#1, Tao Li#1, Zhiru Liu, Pengfei Li, Yongcan Zhou, Yun Sun*. Molecular characterization and expression analysis of B-cell lymphoma-2 in Trachinotus ovatus (TroBcl-2) and its role in apoptotic process. Frontiers in Immunology, 2023, 14: 1129800.

2. Yun Sun#1, Zhenjie Cao#1, Panpan Zhang, Caoying Wei, Jianlong Li, Ying Wu*, Yongcan Zhou*. IFN regulatory factor 3 of golden pompano and its NLS domain are involved in antibacterial innate immunity and regulate the expression of type I interferon (IFNa3). Frontiers in immunology, 2023, 14: 1128196.

3. Yang Lei#1, Zhenjie Cao#1, Yongwei Hou, Xiangyu Du, Han Zhang, Hehe Du, Yongcan Zhou*, Yun Sun*. Molecular characterization and functional analysis of tartrate-resistant acid phosphatase (ACP5) gene in red drum (Sciaenops ocellatus). Fish & Shellfish Immunology, 2023, 132, 108495.

4. Han Zhang, Haoran Yang, Pengsuo Li, Na Zhao, Xiaojuan Chen, Yongcan Zhou, Zhenjie Cao*, Yun Sun*. Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers (Plectropomus leopardus). Journal of Oceanology and Limnology, 2023, 41(3), 1084-1099.

5. Hehe Du#1, Zhenjie Cao#1, Zhiru Liu, Guotao Wang, Ying Wu, Xiangyu Du, Caoying Wei, Yun Sun*, Yongcan Zhou*. Cromileptes altivelis microRNA transcriptome analysis upon nervous necrosis virus (NNV) infection and the effect of cal-miR-155 on cells apoptosis and virus replication. Viruses, 2022, 14, 2184.

6. Han Zhang#1, Zhenjie Cao#1, Qianying Diao, Yongcan Zhou, Jingqun Ao, Chunsheng Liu*, Yun Sun*. Antimicrobial activity and mechanisms of a derived antimicrobial peptide TroNKL-27 from golden pompano (Trachinotus ovatus) NK-lysin. Fish & Shellfish Immunology, 2022. 126, 357-369.

7. Han Zhang, Haoran Yang, Pengsuo Li, Na Zhao, Xiaojuan Chen, Yongcan Zhou, Cao, Zhenjie Cao*, Yun Sun*. Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers (Plectropomus leopardus). Journal of Oceanology and Limnology, 2022, https://doi.org/ 10.1007/s00343-022-2027-z.

8. Xiaojuan Chen#1, Zhenjie Cao#1, Zhengshi Zhang, Ying Wu, HeHe Du, Yun Sun*, Yongcan Zhou*. B lymphocyte stimulating factor of Trachinotus ovatus (TroBLyS) promotes antibacterial immune defense. Aquaculture, 2021, 536:736437.

9. Yixuan Liu#1, Caoying Wei#1, Zhiru Liu, Zhenjie Cao*, Yun Sun*, Yongcan Zhou, Shifeng Wang, Weiliang Guo. Establishment of a new fish cell line from the brain of humpback grouper (Cromileptes altivelis) and its application in toxicology and bacterial susceptibility. Fish Physiology and Biochemistry, 2021. 47(5), 1645-1658.

10. Lu Wang#1, Zhenjie Cao#1, Yixuan Liu, Yajing Xiang, Yun Sun*, Yongcan Zhou*, Shifeng Wang, Weiliang Guo. Establishment and characterization of a new cell line from the muscle of humpback grouper (Cromileptes altivelis). Fish Physiology and Biochemistry, 2020, 46, 1897-1907.

11. Xiaojuan Chen#, Yun Sun#, Panpan Zhang, Jianlong Li, Haiping Li, Caoying Wei, Zhenjie Cao*, Yongcan Zhou*. Screening of stable internal reference genes by quantitative real-time PCR in humpback grouper (Cromileptes altivelis). Journal of Oceanology and Limnology, 2020, 1-15.

12. Yun Sun, Yajing Xiang, Mingwang He, Xiang Zhang, Shifeng Wang, Weiliang Guo, Chunsheng Liu, Zhenjie Cao*, Yongcan Zhou*. Evaluation of Lactococcus lactis HNL12 combined with Schizochytrium limacinum algal meal in diets for humpback grouper (Cromileptes altivelis). Fish & Shellfish Immunology, 2019. 94: 880-888.

13. Zhenjie Cao, Xiaocen Liu, Yajing Xiang, Lu Wang, Yun Sun, Yongcan Zhou. Genetic polymorphism of MHC class IIα alleles and its association with resistance/susceptibility to viral nervous necrosis virus (VNNV) in golden pompano (Trachinotus ovatus). Aquaculture, 2019, 501:144-152.

14. Zhenjie Cao, Lu Wang, Yajing Xiang, Xiaocen Liu, Zhigang Tu, Yun Sun, Yongcan Zhou. MHC class IIα polymorphism and its association with resistance susceptibility to Vibrio harveyi in golden pompano (Trachinotus ovatus). Fish & Shellfish Immunology, 2018, 80:302-310.

15. Zhenjie Cao, Mingwang He, Xiaojuan Chen, Shifeng Wang, Yan Cai, Zhenyu Xie, Yun Sun, Yongcan Zhou. Identification, polymorphism and expression of MHC class Iα in golden pompano, Trachinotus ovatus. Fish & Shellfish Immunology, 2017, 67: 55-65.

16. 孙云，何明旺，张盼盼，李海平，曹贞洁*，周永灿*. 美洲鳗鲡致病性鲍曼不动杆菌的分离、鉴定及致病性分析. 水产学报, 2020, 44(9): 1561−1571.

招生专业

水产学术硕士、渔业发展专业硕士，欢迎同学们积极联系报考。

联系方式

电子邮箱：czj203@126.com