张冬冬

副教授 博士生导师

个人简介

中国海洋大学 生物科学学士、水生生物学硕士，美国奥本大学（Auburn University）水产渔业科学博士。2019年10月入职海南大学，副教授，硕士、博士生导师，海南省D类高层次人才。主持国家自然科学基金、海南省自然科学基金等多项科研项目，在 Fish and Shellfish Immunology和Aquaculture等杂志发表SCI论文30余篇，申请发明专利7项，参编研究生《水产动物免疫学》教材一部。部分研究成果已在国际学术会议上进行交流，例如在首届港珠澳海洋产业发展论坛暨中国-东盟海水养殖产业发展论坛中报告了鱼类黏膜健康与疾病管理相关研究，并在世界水产养殖学会年会（AQUA 2024）中担任一疾病分会场主持及作口头学术报告。

研究方向和内容

研究方向为水产动物免疫与疾病学，主要聚焦以下方面：运用免疫学、分子生物学及多组学技术，解析鱼类黏膜免疫细胞分型及病原-宿主互作机制；研发水产病原快速检测技术及绿色防控策略；筛选重要疾病的抗病基因与分子标记，服务于抗病育种实践。相关研究为鱼类免疫机制解析和养殖病害绿色防控提供了理论基础与技术支撑。

主持科研项目

1.国家自然科学基金青年项目，罗非鱼鼠李糖凝集素介导柱状黄杆菌粘附侵染的分子机制，2024-01至2026-12，主持。

2.罗非鱼重要细菌性病原人工感染模型的建立及抗病品系选育项目，横向课题，2023-05至2025-05，主持。

3.海南省自然科学基金项目, 罗非鱼鳃黏膜组织细胞分型, 2020-12 至 2023-12，主持。

4.海南省重大科技计划项目子任务，高体鰤人工繁育与安全生产关键技术研究与应用示范-疾病防控，2021-12 至 2024-12，主持。

5.广东省水产经济动物病原生物学及流行病学重点实验室开放课题，罗非鱼柱状黄杆菌病原侵染机制研究，2021-09 至 2023-09, 主持。

6.海南大学高层次人才科研启动项目，海南重要养殖鱼类分子免疫机制研究，2020-01到2024-12，主持。

代表论文

1.Zhang D., Peatman E., Beck B.H., Zhao H., Mazzola J., Su B., Elaswad A.*, Ye Z*. (2025). Liver and intestine transcriptome analysis reveals molecular mechanisms of phytase-driven nutrient utilization and metabolic regulation in hybrid catfish. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 56: 101539.

2.Chen M., Zhou Y., Wang S., Luo J., Guo W., Deng H., Zheng P., Zhong Z., Su B., Zhang D.*, Ye Z*. (2025). Development of a Real-time enzymatic recombinase amplification assay (RT-ERA) and an ERA combined with a lateral flow dipstick (LFD) assay (ERA-LFD) for enteric microsporidian (Enterospora epinepheli) in grouper fishes. Biology, 14(4):330. (Corresponding author)

3.Xu Y., Wang S., Zhou Y., Xie Z., Wang B., Zhao Z., Cai W., Wang P., Guo W., Zhang D.*, Ye Z*. (2024). Immune suppression and rapid invasion of Nile tilapia gills following an acute challenge by Flavobacterium davisii. Biology, 13(11):894. (Corresponding author)

4.Zhou G., Ye Z., Luo J., Zhang D.*, Thongda W., Chen M., Wang S., Guo W., Deng H., Li J., Cai Y., Zhou Y*. (2024). Intestinal microbiota and gene expression alterations in leopard coral grouper (Plectropomus leopardus) under enteritis. Fish and Shellfish Immunology, 150:109644. (Corresponding author)

5.Zhang D., Zhou G., Thongda W., Li C., Zhi Ye, Zhao H., Beck B.H., Mohammed H., Peatman E*. (2024). Early divergent responses to virulent and attenuated vaccine isolates of Flavobacterium columnare in channel catfish, Ictalurus punctatus. Fish and Shellfish Immunology, 144:109248.

6.Wang P., Zhou Y., Wang B., Elaswad A., Wang S., Guo W., Zhang D*. (2023). Single-cell suspension preparation from Nile tilapia intestine for single-cell sequencing. Journal of Visualized Experiments, (192):1–12. (Corresponding author)

7.Zhang D., Mohammed H., Ye Z., Rhodes M.A., Thongda W., Zhao H., Jescovitch L.N., Fuller S.A., Davis D.A., Peatman E*. (2022). Transcriptomic profiles of Florida pompano (Trachinotus carolinus) gill following infection by the ectoparasite Amyloodinium ocellatum. Fish and Shellfish Immunology, 125:171–179.

8.Zhang D., Thongda W., Li C., Zhao H., Beck B.H., Mohammed H., Arias C.R., Peatman E*. (2017). More than just antibodies: Protective mechanisms of a mucosal vaccine against fish pathogen Flavobacterium columnare. Fish and Shellfish Immunology, 71:160–170.

9.Zhang D., Beck B.H., Zhao H., Thongda W., Ye Z., Zeng Q., Shoemaker C.A., Fuller S.A., Peatman E*. (2018). L-Rhamnose-binding lectins (RBLs) in Nile tilapia, Oreochromis niloticus: characterization and expression profiling in mucosal tissues. Fish and Shellfish Immunology, 72:426–435.

10.Zhang D., Beck B.H., Lange M., Zhao H., Thongda W., Ye Z., Li C., Peatman E*. (2017). Impact of oral and waterborne administration of rhamnolipids on the susceptibility of channel catfish (Ictalurus punctatus) to Flavobacterium columnare infection. Fish and Shellfish Immunology, 60:44–49.

11.Zhou Y.^#, Zhang D.^#, Peatman E., Rhodes M.A., Liu J., Davis D.A*. (2017). Effects of various levels of dietary copper supplementation with copper sulfate and copper hydroxychloride on Pacific white shrimp Litopenaeus vannamei performance and microbial communities. Aquaculture, 476:94–105. (Co-first author)

招生专业

水生生物学博士、水产养殖学术硕士、渔业发展专业硕士

联系方式

电子邮箱：zdd88312@hainanu.edu.cn

办公室：南海海洋资源利用国家重点实验室 517